Human metapneumovirus is capable of entering cells by fusion with endosomal membranes

HIGHLIGHTS

• who: Reagan G. Cox et al. from the University School of Medicine have published the article: Human Metapneumovirus Is Capable of Entering Cells by Fusion with Endosomal Membranes, in the Journal: (JOURNAL)
• what: The authors sought to determine the cellular site of HMPV fusion. The authors show that HMPV particles are internalized by clathrin-mediated endocytosis and fuse with endosomal Furthermore HMPV engages RGD-binding integrins for endosomal trafficking and full virus membrane fusion with intracellular suggesting that HMPV uses integrins to facilitate movement into target cells rather than as a trigger for fusion at . . .
  

   

  

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