Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts

HIGHLIGHTS

  • who: Dylan Mostert and colleagues from the Department of Biomedical Engineering, Eindhoven University of Technology, , MB Eindhoven, The Netherlands have published the Article: Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts, in the Journal: Scilight 2022, 521102 (2022) of 20/Dec/2022
  • what: The authors investigate the singular and combined effect of ECM (dis)organization and cyclic strain in a two-dimensional human in vitro co-culture model of the myocardial microenvironment. The authors show that (an)isotropic ECM protein patterning can guide the orientation of CMs and . . .

     

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