Human ramp1 overexpressing mice are resistant to migraine therapies for motion sensitivity

HIGHLIGHTS

  • What: The authors aim to characterize the effects of CGRP in nestin/hRAMP1 mice by employing postural sway assays, and motion-induced thermoregulation-a nausea surrogate assay. The authors seek to determine whether olcegepant or rizatriptan can provide protection against any CGRP-induced or endogenous changes in the hypersensitized CGRP receptor mouse. A constraint to the model was applied so that the x-intercept analyzed occurred after time=20 minutes.
  • Who: Shafaqat M. Rahman and colleagues from the Department of Biomedical Engineering, of Rochester, Rochester, NY, United States of America have published the research work . . .

     

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