HIGHLIGHTS
- What: The study provides insights into characterising the dysregulation of VCP mutant microglia.
- Who: Benjamin E. Clarke from the (UNIVERSITY) have published the research: Molecular Neurodegeneration Human VCP mutant ALS/FTD microglia independently of GPNMB, in the Journal: (JOURNAL)
- How: The authors used quantitative immunofluorescence to compare the expression of microglial markers in hiPSC-derived microglia with hiPSC-derived macrophages differentiated for the same number of days in_vitro.
- Future: Work is required to understand the contribution of IL-6 and CXCL10 to ALS.
SUMMARY
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