Humanized 2 integrin-expressing hoxb8 cells serve as model to study integrin activation

HIGHLIGHTS

• who: Thomas Bromberger and colleagues from the Institute of Experimental Hematology, School of Medicine, Technische Universitu00e4t Mu00fcnchen have published the Article: Humanized 2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation, in the Journal: Cells 2022, 1532 of 25/02/2022
• what: The authors report the generation of a Hoxb8 cell line expressing human u03b22 integrin that functionally replaced the deleted mouse ortholog. The authors show that humanized u03b22 PMN-like cells can be activated by various agonists such as TNFu03b1, CXCL1, fMLP, or PMA that trigger integrin inside-out signaling pathways . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.