Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy

HIGHLIGHTS

• who: Kan-Xing Wu from the Lee Kong Chian School of Medicine, Nanyang Technological University have published the article: Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy, in the Journal: (JOURNAL)
• what: The authors focused on HYAL1 as a modifiable target. The authors report single-cell analysis of the differential responses of human endothelial cells from healthy controls and PCV patients to heterogeneous flow.
• how: The authors developed the BOEC models from peripheral blood mononuclear cell (PBMC) fractions isolated from PCV and normal donors according to established protocol . Bar . . .
  

   

  

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