Hydroxyurea down-regulates bcl11a, klf-1 and myb through mirna-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease

HIGHLIGHTS

• who: Gift Dineo Pule from the Division of Human Genetics, Faculty of Health Sciences, University of South Africa have published the research: Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease, in the Journal: (JOURNAL)
• what: This study has further investigated whether the induction of HbF by HU treatment could operate through post-transcriptional regulation of BCL11A, KLF-1 and MYB, by analysing changes in expression of select miRNAs in erythroid cells derived from umbilical cord blood CD34+ hematopoietic . . .
  

   

  

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