HIGHLIGHTS
- who: Raymond T. Anderson from the Department of Biochemistry, West Virginia University School of Medicine, Medical Center Dr have published the paper: Hyperactivation of the proteasome in Caenorhabditis elegans protects against proteotoxic stress and extends lifespan, in the Journal: (JOURNAL)
- what: The authors examine how this hyperactive proteasome affects C. elegans biology and impacts its lifespan, and resistance to oxidative and proteotoxic stresses.
- how: Given the high sequence conservation of the α3 N-terminus among eukaryotes (Fig 1B) the authors hypothesized that making this mutation in nematodes would also induce gate opening and . . .
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