Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mtorc1 and casr-gq signaling pathways

HIGHLIGHTS

• who: Yulong Gong from the (UNIVERSITY) have published the Article: Hyperaminoacidemia induces pancreatic u03b1 cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways, in the Journal: (JOURNAL) of 20/Dec/2022
• what: Using both genders of mouse islets and glucagon receptor (gcgr)-deficient zebrafish (Danio rerio), the authors show u03b1 cell proliferation requires activation of the extracellular signal-regulated protein kinase (ERK1/2) by the AA-sensitive calcium sensing receptor (CaSR). The authors show that CaSR-activated Mek1/2 also contributes to mTORC1 activation. Previous studies also revealed a role for CaSR . . .
  

   

  

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