Hyperbaric oxygen therapy reduces the traumatic brain injury–mediated neuroinflammation through enrichment of prevotella copri in the gut of male rats

HIGHLIGHTS

• What: The study demonstrated how the neuroprotective effects of HBO after acute TBI might act through reshaping the TBI-induced gut dysbiosis and reversing the TBI-mediated decrease of Prevotella copri. The authors hypothesized that post-TBI treatment with HBO alters the gastrointestinal microbiome correlating with structural and functional characteristics of the brain, with a focus on neuroinflammation. The analysis revealed 39 functional pathways in the sham and TBI2.0 group (Fig 8A), while only one functional pathway was identified in the sham and TBI2.0 + HBO group (Fig 8B) (n=6 in each group).
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