Hyperglycemia aggravates ischemic brain damage via erk1/2 activated cell autophagy and mitochondrial fission

HIGHLIGHTS

• who: Ping Liu from the Hirosaki University, Japan have published the Article: Hyperglycemia aggravates ischemic brain damage via ERK1/2 activated cell autophagy and mitochondrial fission, in the Journal: (JOURNAL)
• what: In this study, the neurological behavior scores and celebral I/R induced infarct volume treated with or without PD98059 were compared in DM rats.
• how: The above data showed that ERK1/2 inhibitor administration might play a neuroprotective function by maintaining the mitochondrial membrane potential and reducing cell apoptosis. The results showed that compared with the Sham group the JC-1 ratio . . .
  

   

  

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