HIGHLIGHTS
- who: Changcheng Zhou from the LaboratoryRockefeller University have published the research: Hyperglycemic Ins2AkitaLdlr−/− mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease[S], in the Journal: (JOURNAL) of 26/04/2011
- how: To GSEA the microarray results were analyzed by IPA Canonical Pathway Analysis.
SUMMARY
Akita mouse. To enable studies of the effect of hyperglycemia on atherosclerosis, the authors bred the Ins2Akita trait onto the atherosclerosis-susceptible Ldlr⫺/⫺ background and compared Ins2AkitaLdlr⫺/⫺ to Ldlr⫺/⫺ controls. Liver gene_expression revealed alteration in lipid homeostasis genes . . .
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