Hyperinsulinemia-induced microglial mitochondrial dynamic and metabolic alterations lead to neuroinflammation in vivo and in vitro

HIGHLIGHTS

  • who: Jianmei Ma from the Lund University, Sweden Sapienza University of Rome, Italy have published the Article: Hyperinsulinemia-induced microglial mitochondrial dynamic and metabolic alterations lead to neuroinflammation in vivo and in vitro, in the Journal: (JOURNAL)
  • what: The studies of insulin action in brain mainly focus on the states and functions of neurons, such as neurosynaptic regulation, neuronal polarization, and survival (Mielke and Wang, 2011; Grasso et_al, 2013), but less on glial cells, especially microglia. In present study, the authors analyzed membranous and total GLUT4 expression in insulin- treated BV2 cells and primary microglia . . .

     

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