HIGHLIGHTS
- who: Jonathan X. Meng from the University of Cambridge, Cambridge, UK have published the paper: Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: Using this approach, the authors achieved a mean localization precision of 18.9 nm and an image resolution of 29.4 nm, determined by Fourier ring correlation analysis (Supplementary Fig 4e, f). This study showed that hyperphosphorylated tau aggregates could trigger TLR4-dependent pro-inflammatory reactions in human macrophages (both THP-1 cell line and primary human cells).
- how . . .
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