HIGHLIGHTS
- who: Xiaomeng Hu from the (UNIVERSITY) have published the paper: Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice, in the Journal: (JOURNAL) of 24/09/2022
- what: The authors aimed to develop universal allogeneic CAR T_cells that evade the immune system and produce a durable response. There was no difference in cytotoxicity between the two CAR groups at the same dose level. human CD34+ cord blood-derived hematopoietic stem_cells (HSC), and all humanized mice selected for this study showed at least 45% human CD45+ cells . . .
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