Hypothesis: why different types of sdh gene variants cause divergent tumor phenotypes

HIGHLIGHTS

• who: Jean-Pierre Bayley and Peter Devilee from the Department of Human Genetics, Leiden University Medical Center, ZA Leiden, The Netherlands have published the paper: Hypothesis: Why Different Types of SDH Gene Variants Cause Divergent Tumor Phenotypes, in the Journal: Genes 2022, 13, x FOR PEER REVIEW of /2022/
• what: In scenario 1 the authors propose that missense disrupt electron flow causing elevated ROS levels that are toxic in sympathetic PPGL precursor cells but well controlled in oxygen-sensing parasympathetic paraganglion cells. In scenario 2 the authors propose modified succinate threshold model of initiation. The . . .
  

   

  

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