HIGHLIGHTS
- who: from the Zhejiang University School of Medicine, Hangzhou, Zhejiang, China have published the paper: Hypoxia Confers Tumor with a Higher Immune Infiltration but Lower Mutation Burden in Gastrointestinal Cancer, in the Journal: Journal of Oncology of 12/09/2022
- what: This is one of the important reasons why a high tumor mutational burden (TMB) in patients predict a good clinical response to an immune checkpoint blockade (ICB) and prolonged overall survival (OS) .
- how: The results showed that hypoxia was significantly correlated with worse OS in both the TCGA (log-rank P=0 . . .
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