Hypoxia-inducible factor in thyroid carcinoma

HIGHLIGHTS

• who: Natalie Burrows et al. from the School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester , PT, UK have published the article: Hypoxia-Inducible Factor in Thyroid Carcinoma, in the Journal: (JOURNAL) of 20/04/2011
• what: HIF-1 is potently induced by both hypoxia and oncogenic signalling pathways in thyroid carcinoma, and its expression and activity have been correlated with aggressiveness.
• how: This process is carried out by specific oxygen-dependent enzymes known as proline hydroxylase domain proteins (PHDs).
• future: As HIF-1 is a downstream target . . .
  

   

  

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