HIGHLIGHTS
- who: Violet A. Kiesel and colleagues from the University of Pisa, Italy have published the Article: Hypoxia-Mediated ATF4 Induction Promotes Survival in Detached Conditions in Metastatic Murine Mammary Cancer Cells, in the Journal: (JOURNAL)
- what: This study shows that hypoxia drives differential responses to hypoxic stress in nonmetastatic compared to metastatic murine mammary cancer cells. This work shows that hypoxia increases reductive carboxylation of glutamine-derived aKG to citrate in nonmetastatic cells but decreases this pathway in metastatic cells . Previous literature has identified hypoxia as a regulator of both isocitrate dehydrogenase and SIAH2 in . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.