HIGHLIGHTS
- who: 16jeol from the DivisionWomans University have published the article: Hyunsook Lee, in the Journal: (JOURNAL)
- how: Note that sequencing result showed that BubR1 in lymphoma B was wild_type (Lee et_al 1999).
SUMMARY
In tro d u ctio n Individuals who inherit one defective copy of BRCA2 gene are predisposed to early onset breast cancer and ovarian cancer (W ooster et_al, 1995; Tavtigian et_al, 1996). Tumor cells from predisposed individuals usually contain mutations in both alleles (Collins et_al, 1995; Gudmundsson et_al, 1995), thus BRCA2 works as a tumor suppressor. Murine cells . . .
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