Ibrutinib inhibits antibody dependent cellular cytotoxicity induced by rituximab or obinutuzumab in mcl cell lines, not overcome by addition of lenalidomide

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  • who: Alexandra Albertsson-Lindblad from the (UNIVERSITY) have published the research work: Ibrutinib inhibits antibody dependent cellular cytotoxicity induced by rituximab or obinutuzumab in MCL cell lines, not overcome by addition of lenalidomide, in the Journal: (JOURNAL)
  • what: The authors aimed to investigate whether the reduced response to anti-CD20 mAb treatment by ibrutinib could be prevented by pretreatment of effector cells with the immune modulator lenalidomide (ii). Little is known about how ibrutinib interferes with the immune-mediated activity induced by anti-CD20 targeted treatment in MCL, which was the focus of this study . . .

     

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