HIGHLIGHTS
SUMMARY
Inhibiting CTLA-4 can result in the expansion of CD4+ effector T_cells, while inhibiting PD-1/PD-L1 can reinvigorate exhausted CD8+ T_cells. A series of additional ICI targets have also been investigated, such as the T_cell-expressed inhibitory receptors LAG-3, TIM-3 and TIGIT, and inhibitory ligands in the B7 family. In turn, the immunogenic micro-environment needs to permit proliferation of T_cells and their infiltration into the tumor. Conceptually, a high mutation burden could produce more neoantigens that can be processed and presented for T_cell recognition. The latest research makes use . . .
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