HIGHLIGHTS
SUMMARY
The inducible costimulator (ICOS) is a member of the CD28 superfamily and is known to be expressed by activated T_cells (Hutloff et al, 1999). After sorting, the authors added back-sorted conventional CD4+ Foxp3- T_cells (~10% of total) to the sorted CD4+ Foxp3+ T-cell pool to provide a reference point for Foxp3-null cells (Fig S6A, cluster 4). When ICOS is critical for Tfr differentiation Panneton et_al compared to CD4+ Foxp3- conventional T_cells (Fig S6A, cluster 4), cluster 3 still mostly maintained higher levels of these Treg signature genes, including 10-fold higher . . .
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