HIGHLIGHTS
SUMMARY
In recent years, it has been demonstrated that the incidence of HCC in the United_States has increased from that in previous studies (Ashhab et_al, 2019; Kim and El-Serag, 2019). Despite promising advances such as partial hepatectomy, liver transplantation, interventional surgery, and systemic treatment in treatment of HCC, the long-term outcome of late-stage HCC remains ineffective and essentially palliative (Hartke et_al, 2017; Zhao et_al, 2020). Until now, relatively vague predictions have been provided from extensively applied staging systems in evaluating the options for treatment and prognostic outcomes for patients with HCC (Cao . . .
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