HIGHLIGHTS
- who: . et al. from the National Institutes of Health (NIH), United States School of Biosciences, Cardiff University, Cardiff, United Kingdom, School of Pharmacy and have published the article: Identi cation of a novel P2X7 antagonist using structure-based virtual screening, in the Journal: (JOURNAL)
- how: The authors identified one compound (GP-25 an indeno(12-b)pyridine derivative) with antagonist activity at. net both human and rat P2X7 in an ATP-induced dye uptake (YoPro-1) assay with IC50 values of 8.7 u03bcM at human P2X7 and 24.4 u03bcM at rat P2X7. The . . .
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