HIGHLIGHTS
SUMMARY
Depletion of YTHDF1 in dendritic cells significantly enhances antigen presentation, resulting in CD8+T_cell activation (Han et_al, 2019). Macrophage-specific METTL14 knockout drives CD8+T_cell differentiation in a dysfunctional direction, impairing the ability of CD8+T_cells to eliminate tumors (Dong et_al, 2021). METTL3 mediated gemcitabine, 5fluorouracil, and cisplatin resistance in non-small-cell lung cancer and pancreatic cancer (Taketo et_al, 2018; Jin et_al, 2019). Afterward, consensus clustering analysis based on the gene_expression of 27 m6A RNA methylation regulators was utilized to distinguish three different m6A modification subgroups. High recurrence and unsatisfactory prognosis are still . . .
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