Identi cation of the molecular determinants of antagonist potency in the allosteric binding pocket of human p2x4

HIGHLIGHTS

• who: . and colleagues from the National Institutes of Health (NIH), United States McGill University, Canada have published the paper: Identi cation of the molecular determinants of antagonist potency in the allosteric binding pocket of human P2X4, in the Journal: (JOURNAL)
• what: Using this approach, the authors were able to show that a network of interactions with Arg-82, Asp-85, Ala-87, Asp-88, Trp-164, Ala-297, Glu-307, and Arg-309, deep within the allosteric pocket and critical for efficient P2X4 gating, are likely to be disrupted by antagonist binding. It is difficult . . .
  

   

  

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