Identification of ύ-1-pyrroline-5-carboxylate derived biomarkers for hyperprolinemia type ii

HIGHLIGHTS

• who: Jona Merx from the Institute for Molecules and Materials, Synthetic Organic Chemistry, Heyendaalseweg, AJ Nijmegen, The NetherlandsUniversity have published the research work: Identification of u038e-1-pyrroline-5-carboxylate derived biomarkers for hyperprolinemia type II, in the Journal: (JOURNAL)
• what: Using the previously established approach combining untargeted metabolomics with infrared ion spectroscopy (IRIS) and synthesis of reference standards the authors show here that P5C reacts with acetoacetic acid or malonic acid in an analogous manner as the authors previously elucidated for P6C9 leading to the formation of biomarkers 2-OPC and CPC respectively (Fig . . .
  

   

  

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