Identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion

HIGHLIGHTS

• who: Cassandra M. Burke and colleagues from the Hampshire, United States of America, The Roslin Institute and R(D)SVS, University of Edinburgh, Easter have published the Article: Identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion, in the Journal: (JOURNAL) of August/11,/2020
• what: The authors propose that residues 227 and 230 and the second glycan are part of a C-terminal domain that acts as a linchpin for bank vole and mouse prion conversion. This analysis showed that neither E227D nor S230R substitution alone reduced the . . .
  

   

  

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