HIGHLIGHTS
- who: S. M. Ayala Mariscal from the (UNIVERSITY) have published the research work: Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT, in the Journal: (JOURNAL) of 26/07/2022
- what: Both mutants (DNAJB1F247A and DNAJB1R249A) are not as strongly impaired as DNAJB1H244A and hence the authors focused in the subsequent analyses on H244. particular H244 of DNAJB1 are specifically required for the suppression of HTTExon1Q48 aggregation yet not for every substrate protein. The authors have identified and characterized an interaction interface between DNAJB1/Hsc70 and HTTExon1. Based . . .
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