HIGHLIGHTS
SUMMARY
For instance, VEGF has been found to be highly expressed in GC cancer cells under hypoxia, and activation of HIF-1α promoted angiogenesis. Hypoxia condition has been found to promote endothelial cells, vessel formation by exosome reassembly, and regulatory T_cell employment, and direct causes of angiogenesis by hypoxia was mainly attributed to the upregulated VEGF and reprogramming of cancer cells. lncRNA was recently discovered as a bridge that connects upstream hypoxia genes and downstream targets to activate angiogenesis. RAB11B-AS1 was activated by HIF-2α under hypoxia and interacted with RNA_polymerase II to enhance . . .
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