Identification of a ligand-binding site on the granulocyte colony-stimulating factor receptor by molecular modeling and mutagenesis*

HIGHLIGHTS

• who: Judith E. Layton from the (UNIVERSITY) have published the article: Identification of a Ligand-binding Site on the Granulocyte Colony-stimulating Factor Receptor by Molecular Modeling and Mutagenesis*, in the Journal: (JOURNAL) of June/20,/1997
• what: These residues formed a binding face on the receptor model resembling the growth hormone_receptor site, which suggests that the model is reasonable. This model has been confirmed by determination of the crystal_structures of several receptors including the growth hormone_receptor (GH-R) , prolactin receptor , erythropoietin receptor (EPO-R) , and related class 2 cytokine receptors: tissue factor and interferon . . .
  

   

  

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