HIGHLIGHTS
- who: Michelle Chan from the Animal studies Animals were housed and cared for within the procedures approved by the Columbia University Animal Care and Utilization CommitteeWT and Ppar␣ knockout mice on a C BL/ J background were obtained from Jackson Laboratories. Mice were housed on a, h light/dark cycle with access to regular chow (Pico Lab Diet, Purina Mill Inc [, ]. Brentwood, MO) and water ad libitum. For chronic cold exposure, mice were housed at , °C for , days. To promote DIO, animals were fed a HFD, of which, % of the calories were obtained from fat, % from carbohydrates . . .
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