Identification of amino acid residues within the c terminus of the glut4 glucose transporter that are essential for insulin-stimulated redistribution to the plasma membrane*

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  • who: Song Xiao Mei from the Xiao Mei Song, Richard CHresko, and Mike Mueckler, From the Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri , The Glut, glucose transporter undergoes complex insulinregulated subcellular trafficking in adipocytes. Much effort has been expended in an attempt to identify targeting motifs within Glut, that direct its subcellular trafficking, but an amino acid motif responsible for the targeting of the transporter to insulinresponsive intracellular compartments in the basal state or that is directly responsible for its insulin-stimulated redistribution to the plasma membrane has not yet . . .

     

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