Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase

HIGHLIGHTS

• who: Helen Michels from the European Research InstituteUniversity of have published the article: Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase, in the Journal: Scientific Reports Scientific Reports of 18/07/2014
• what: This finding will help to develop a new family of TDO-specific inhibitors that can target and destabilise this particular loop region, with the overall aim of treating TDO hyperactivity and tryptophan-associated diseases.

SUMMARY

While the crystal_structure of human TDO has now also been . . .

 



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