Identification of binding sites for bepridil and trifluoperazine on cardiac troponin c*

HIGHLIGHTS

  • who: Quinn Kleerekoper from the (UNIVERSITY) have published the research: Identification of Binding Sites for Bepridil and Trifluoperazine on Cardiac Troponin C*, in the Journal: (JOURNAL) of November/26,/1997
  • what: The aim of this study was to generate structural information on the binding of bepridil and TFP to full-length cTnC and to correlate these data with the solution structure of this critical Ca21-regulatory protein.

SUMMARY

    Cardiac muscle contraction is initiated when Ca21 binds to the N-terminal regulatory metal binding_site II in cTnC. Knowledge of the structure of . . .

     

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