Identification of binding sites in the nicotinic acetylcholine receptor for [3h]azietomidate, a photoactivatable general anesthetic*

HIGHLIGHTS

  • who: Michael R. Ziebell from the (UNIVERSITY) have published the research work: Identification of Binding Sites in the Nicotinic Acetylcholine Receptor for [3H]Azietomidate, a Photoactivatable General Anesthetic*, in the Journal: (JOURNAL) of December/18,/2003

SUMMARY

    Each subunit has a large N-terminal domain that contributes to the receptor extracellular domain and four transmembrane segments (M1-M4), organized as a four helix bundle, with M2 segments from each subunit contributing to the lumen of the ion_channel. In the muscle-type nAChR, with a subunit stoichiometry ␣2␤␥␦, the two agonist binding_sites, which are . . .

     

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