Identification of differentially methylated regions in rare diseases from a single-patient perspective

HIGHLIGHTS

• who: Robin Grolaux from the Interuniversity Institute of Bioinformatics in, Universitu00e9 Libre de have published the research: Identification of differentially methylated regions in rare diseases from a single-patient perspective, in the Journal: (JOURNAL) of September/14,/2018
• what: The authors show its diagnostic utility when applied to rare disorders. The authors propose a statistical method based on the Z-score followed by the Empirical Brown method that takes into account covariance between variables to identify DMRs in a single-patient setting. The authors characterize the behavior of CpGs methylation status in various regions of . . .
  

   

  

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