Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by rna-based therapeutics

HIGHLIGHTS

• who: Daisuke Ogiya from the (UNIVERSITY) have published the research work: Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by RNA-based therapeutics, in the Journal: (JOURNAL) of 27/01/2022
• what: Considering toxicity, efficacy, and tissue uptake of RNA, the authors propose two viable strategies (Fig 4A).

SUMMARY

The pre-mRNA sequence elements that determine splicing specificity are classical splice sites such as 5` (donor) and 3` (acceptor) splice sites, a splicing branch point (BP), and polypyrimidine tracts (PPTs) of splicing. This SNP . . .

 



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