Identification of ferroptosis-related genes and pathways in diabetic kidney disease using bioinformatics analysis

HIGHLIGHTS

SUMMARY

    Principal component analysis (PCA) showed that the expression profile of normal kidney tissue was significantly different from that of the DKD group (Fig 1c). Through gene pathway enrichment analysis, the authors can preliminarily analyze the biological processes or signal pathways that may be involved in the occurrence and development of DKD. To further explore the differences of function and pathway between DKD and normal groups, the authors used GSEA to perform enrichment analysis on the differential gene list ranked from high to low in the logFC of the GO, KEGG, and MSigDb pathway-related . . .

     

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