Identification of ferroptosis-related genes for overall survival prediction in hepatocellular carcinoma

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SUMMARY

    Intersecting two datasets to get a list of 200 ferroptosis-related genes with their expression profile in the TCGA-LIHC cohort. The analysis identified 126 differentially expressed FRGs, including 110 high expressed genes and 16 low expressed genes (Fig 2A). The authors tried to describe the overall condition of the simple nucleotide variation for 126 differentially expressed genes (DEGs). To understand what role FRGs play in the HCC more deeply, the authors applied univariate Cox regression analysis and received 19 prognostic genes. The LASSO (Least Absolute Shrinkage and Selection Operator) regression analysis was used . . .

     

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