HIGHLIGHTS
SUMMARY
The clusterProfiler package in R was used to identify the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG)22-24 pathways characterizing DE-FRGs and hub LN-FRGs, as well as to explore their potential biological processes, cellular components, molecular functions, and important signaling pathways. CIBERSORT was shown to transform a normalized gene_expression matrix into the composition of 22 immune cell types based on a deconvolution algorithm25. Pearson correlation matrix analysis was performed on the GSE112943 immune infiltrating cell profile analyzed by CIBERSORT and the gene_expression profile of this dataset. ThE . . .
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