HIGHLIGHTS
SUMMARY
The intersection between IRDEGs of lung tissue and PBMCs from patients with or without IPAH were taken and hub genes of IPAH were further identified from the intersection using machine_learning algorithm. Integrated bioinformatic analysis of PBMCs gene_expression dataset of patients with IPAH might reveal new mechanisms of IPAH. This study aimed to construct IPAH-related gene co-expression networks, conduct enrichment analysis, analyze the infiltration of immune cells in lung tissues from patients with IPAH, Frontiers in Cardiovascular Medicine The dysregulation of hub genes in lung tissues and PBMCs samples emphasized the crucial roles . . .
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