Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design

HIGHLIGHTS

• who: Robert F. Hillary from the (UNIVERSITY) have published the research work: Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design, in the Journal: (JOURNAL)
• what: The authors focus on the Beta-value (derived from Illumina arrays) as it has a simpler biological interpretation and therefore allows the authors to intuitively categorise probes into hypo- and hypermethylated sites (mean Beta-value ≤ 10% or ≥ 90% across individuals), which may reflect invariant probes. The variances explained by these predictors are also smaller than those from REML, reflecting disparate methodologies and analysis . . .
  

   

  

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