Identification of novel 4`-o-demethyl-epipodophyllotoxin derivatives as antitumor agents targeting topoisomerase ii

HIGHLIGHTS

• who: Wenli Xi and colleagues from the Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina have published the research: Identification of Novel 4`-O-Demethyl-epipodophyllotoxin Derivatives as Antitumor Agents Targeting Topoisomerase II, in the Journal: Molecules 2022, 502922 of /2022/
• what: Since 40 -demethyl-epipodophyllotoxin (DMEP, on 4) is the fundamental scaffold required To fully explore the effects of C4 substituents the antitumor profiles . . .
  

   

  

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