Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels*

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  • who: Chaojian Wang from the Chaojian Wang1, Chuan Wang1, Ethan GHoch, and Geoffrey S. Pitt, From the Ion Channel Research Unit, Department of Medicine, Duke University Medical Center, Durham, North Carolina , Fibroblast growth factor homologous factors (FHFs, FGF11-, ) bind to the C termini (CTs) of specific voltage-gated sodium channels (VGSC) and thereby regulate their function. The effect of an individual FHF on a specific VGSC varies greatly depending upon the individual FHF isoform. How individual FHFs impart distinctive effects on specific VGSCs is not known and the specificity of these pairwise interactions is not understood. Using . . .

     

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