Identification of p130 cas as an in vivosubstrate of receptor protein-tyrosine phosphatase α*

HIGHLIGHTS

• who: Arjan Buist from the (UNIVERSITY) have published the research: Identification of p130 cas as an in VivoSubstrate of Receptor Protein-tyrosine Phosphatase α*, in the Journal: (JOURNAL) of February/29,/2000
• what: The authors demonstrate that GST-RPTP␣-D2 did not bind any Tyr(P)-containing proteins from pervanadate-treated cells (Fig 1).
• how: Similar results were obtained using NIH3T3 cells instead of P19 EC cells.

SUMMARY

To identify substrates of PTPs, "substrate trapping" mutants have been designed. For instance, mutation of the highly conserved Asp residue from the . . .

 



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