Identification of parn nuclease activity inhibitors by computational-based docking and high-throughput screening

HIGHLIGHTS

• who: Thao Ngoc Huynh from the DepartmentUniversity of have published the article: Identification of PARN nuclease activity inhibitors by computational-based docking and high-throughput screening, in the Journal: Scientific Reports Scientific Reports
• what: The activity was dependent on PARN since PARNmut protein showed no removal of the 3u2032 adenosines (Fig 2c). The authors report the identification of PARN inhibitors in_vitro and in cells.
• how: To identify PARN inhibitors in a highthroughput manner 24000 compounds from the Enamine kinase library were tested in a HTS utilizing the | 135244 | 3 Vol.(0123456789) Examine inhibitory . . .
  

   

  

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