Identification of small molecule inhibitors of pseudomonas aeruginosa exoenzyme s using a yeast phenotypic screen

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  • who: Anthony Arnoldo et al. from the Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada, Department of Molecular have published the article: Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen, in the Journal: (JOURNAL) of February/29,/2008
  • what: The authors demonstrate that a cell-based yeast phenotypic assay combined with a large-scale inhibitor screen identified small molecule inhibitors that can suppress the toxicity caused by heterologous expression of selected Pseudomonas aeruginosa ORFs. The authors show that this inhibitor . . .

     

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