Identification of src family kinases as potential therapeutic targets for chemotherapy-resistant triple negative breast cancer

HIGHLIGHTS

  • who: Ishwar N. Kohale and collaborators from the Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA have published the Article: Identification of Src Family Kinases as Potential Therapeutic Targets for Chemotherapy-Resistant Triple Negative Breast Cancer, in the Journal: (JOURNAL)
  • what: This analysis demonstrated that only one out of the 13 (~8%) of TNBC tumors were potentially driven by SFKs. The authors used pTyr based biomarkers to assess which PDX models and patient tumor specimens demonstrated evidence for high SFK activity and to quantify target inhibition by dasatinib.
  • how: To . . .

     

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